Endocrine Abstracts

Previous studies demonstrated that the N-terminal peptide of annexin A1 (AnxA1) (peptide Ac2-26) can mimic the anti-inflammatory actions of the full-length protein in various systems. In the current study, we report the effectiveness of the peptide Ac2-26 as an anti-inflammatory agent in a model of human SGBS adipocytes. We have previously demonstrated that plasma AnxA1 protein is significantly inversely correlated with BMI, body fat level and waist to hip ratio. We have also ...

Adrenal steroids and alterations in steroid metabolism are important factors in the development of obesity in Zucker rats. One might predict, therefore, that the function of the adrenal gland differs between lean and obese Zucker animals. Accordingly, we investigated adrenal gland morphology and function and have considered not only glucocorticoids and HPA activity but also the renin-angiotensin-aldosterone system. Plasma samples and adrenal glands were obtained from young 12 ...